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A spectrum of diseases, in modern civilisation, are associated with sugar damage. Such diseases include Diabetes, Heart Diseases, Alzheimer’s and a variety of conditions such as hardening of arteries, raised blood pressure, abdominal obesity and ageing skin.  There are mainly two ways in which sugars can cause such disease and damage.

1. Oxidative Stress

Damage can be caused by reactive oxygen species (ROS) that are produced by the burning of blood sugar (Glucose) and oxygen in our cells to  produce energy. 1% of the glucose produces free radicals that can cause oxidation damage to surrounding tissues (oxidative stress). The body uses a variety of anti-oxidants (secondary functions of Co-enzyme Q10 and Cholesterol) to control or limit such damage but as we age such defences may be overwhelmed.  The rate of damage may exceed the rate of repair.

2. AGEs (Advanced Glycaemic End-products)

This sugar damage is the uncontrolled (non-enzymic) attachment of excess blood sugar molecules (fructose and glucose) to proteins (such as collagen, elastin and receptors) around the body.  Over time this gives rise to sugar-damaged proteins known as appropriately as Advanced Glycaemic End-products (AGEs). These AGEs cause, joints, arteries, heart, lungs and skin etc. to lose their elasticity.


The transport of the fat soluble nutrients (including vitamins A, D & E )  to all the organs of the body rely upon Lipids (fatty droplets) produced by the liver and circulating in the blood in the blood.   A simplified version of this mechanism has the liver sending large particles (LDL) to deliver the nutrients and the tissues returning smaller particles (HDL) for recycling.  The particles have apolipoproteins (APO) as labels  the to identify their destination and purpose. Matching receptors are deployed on tissues to latch onto the lipids droplets they require.   When the labels and receptors are damaged by attached sugars, the tissues cannot get the fats they require and the fats are scavenged by visceral fat cells in the abdomen.  This causes a cascade leading to a variety of AGE related diseases as we age.









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